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scientific-skills/benchling-integration/references/sdk_reference.md

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+# Benchling Python SDK Reference
+
+## Installation & Setup
+
+### Installation
+
+```bash
+# Stable release
+pip install benchling-sdk
+
+# With Poetry
+poetry add benchling-sdk
+
+# Pre-release/preview versions (not recommended for production)
+pip install benchling-sdk --pre
+poetry add benchling-sdk --allow-prereleases
+```
+
+### Requirements
+- Python 3.7 or higher
+- API access enabled on your Benchling tenant
+
+### Basic Initialization
+
+```python
+from benchling_sdk.benchling import Benchling
+from benchling_sdk.auth.api_key_auth import ApiKeyAuth
+
+benchling = Benchling(
+    url="https://your-tenant.benchling.com",
+    auth_method=ApiKeyAuth("your_api_key")
+)
+```
+
+## SDK Architecture
+
+### Main Classes
+
+**Benchling Client:**
+The `benchling_sdk.benchling.Benchling` class is the root of all SDK interactions. It provides access to all resource endpoints:
+
+```python
+benchling.dna_sequences      # DNA sequence operations
+benchling.rna_sequences      # RNA sequence operations
+benchling.aa_sequences       # Amino acid sequence operations
+benchling.custom_entities    # Custom entity operations
+benchling.mixtures           # Mixture operations
+benchling.containers         # Container operations
+benchling.boxes              # Box operations
+benchling.locations          # Location operations
+benchling.plates             # Plate operations
+benchling.entries            # Notebook entry operations
+benchling.workflow_tasks     # Workflow task operations
+benchling.requests           # Request operations
+benchling.folders            # Folder operations
+benchling.projects           # Project operations
+benchling.users              # User operations
+benchling.teams              # Team operations
+```
+
+### Resource Pattern
+
+All resources follow a consistent CRUD pattern:
+
+```python
+# Create
+resource.create(CreateModel(...))
+
+# Read (single)
+resource.get(id="resource_id")
+
+# Read (list)
+resource.list(optional_filters...)
+
+# Update
+resource.update(id="resource_id", UpdateModel(...))
+
+# Archive/Delete
+resource.archive(id="resource_id")
+```
+
+## Entity Management
+
+### DNA Sequences
+
+**Create:**
+```python
+from benchling_sdk.models import DnaSequenceCreate
+
+sequence = benchling.dna_sequences.create(
+    DnaSequenceCreate(
+        name="pET28a-GFP",
+        bases="ATCGATCGATCG",
+        is_circular=True,
+        folder_id="fld_abc123",
+        schema_id="ts_abc123",
+        fields=benchling.models.fields({
+            "gene_name": "GFP",
+            "resistance": "Kanamycin",
+            "copy_number": "High"
+        })
+    )
+)
+```
+
+**Read:**
+```python
+# Get by ID
+seq = benchling.dna_sequences.get(sequence_id="seq_abc123")
+print(f"{seq.name}: {len(seq.bases)} bp")
+
+# List with filters
+sequences = benchling.dna_sequences.list(
+    folder_id="fld_abc123",
+    schema_id="ts_abc123",
+    name="pET28a"  # Filter by name
+)
+
+for page in sequences:
+    for seq in page:
+        print(f"{seq.id}: {seq.name}")
+```
+
+**Update:**
+```python
+from benchling_sdk.models import DnaSequenceUpdate
+
+updated = benchling.dna_sequences.update(
+    sequence_id="seq_abc123",
+    dna_sequence=DnaSequenceUpdate(
+        name="pET28a-GFP-v2",
+        fields=benchling.models.fields({
+            "gene_name": "eGFP",
+            "notes": "Codon optimized"
+        })
+    )
+)
+```
+
+**Archive:**
+```python
+benchling.dna_sequences.archive(
+    sequence_id="seq_abc123",
+    reason="Deprecated construct"
+)
+```
+
+### RNA Sequences
+
+Similar pattern to DNA sequences:
+
+```python
+from benchling_sdk.models import RnaSequenceCreate, RnaSequenceUpdate
+
+# Create
+rna = benchling.rna_sequences.create(
+    RnaSequenceCreate(
+        name="gRNA-target1",
+        bases="AUCGAUCGAUCG",
+        folder_id="fld_abc123",
+        fields=benchling.models.fields({
+            "target_gene": "TP53",
+            "off_target_score": "95"
+        })
+    )
+)
+
+# Update
+updated_rna = benchling.rna_sequences.update(
+    rna_sequence_id=rna.id,
+    rna_sequence=RnaSequenceUpdate(
+        fields=benchling.models.fields({
+            "validated": "Yes"
+        })
+    )
+)
+```
+
+### Amino Acid (Protein) Sequences
+
+```python
+from benchling_sdk.models import AaSequenceCreate
+
+protein = benchling.aa_sequences.create(
+    AaSequenceCreate(
+        name="Green Fluorescent Protein",
+        amino_acids="MSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKF",
+        folder_id="fld_abc123",
+        fields=benchling.models.fields({
+            "molecular_weight": "27000",
+            "extinction_coefficient": "21000"
+        })
+    )
+)
+```
+
+### Custom Entities
+
+Custom entities are defined by your tenant's schemas:
+
+```python
+from benchling_sdk.models import CustomEntityCreate, CustomEntityUpdate
+
+# Create
+cell_line = benchling.custom_entities.create(
+    CustomEntityCreate(
+        name="HEK293T-Clone5",
+        schema_id="ts_cellline_abc123",
+        folder_id="fld_abc123",
+        fields=benchling.models.fields({
+            "passage_number": "15",
+            "mycoplasma_test": "Negative",
+            "freezing_date": "2025-10-15"
+        })
+    )
+)
+
+# Update
+updated_cell_line = benchling.custom_entities.update(
+    entity_id=cell_line.id,
+    custom_entity=CustomEntityUpdate(
+        fields=benchling.models.fields({
+            "passage_number": "16",
+            "notes": "Expanded for experiment"
+        })
+    )
+)
+```
+
+### Mixtures
+
+Mixtures combine multiple components:
+
+```python
+from benchling_sdk.models import MixtureCreate, IngredientCreate
+
+mixture = benchling.mixtures.create(
+    MixtureCreate(
+        name="LB-Amp Media",
+        folder_id="fld_abc123",
+        schema_id="ts_mixture_abc123",
+        ingredients=[
+            IngredientCreate(
+                component_entity_id="ent_lb_base",
+                amount="1000 mL"
+            ),
+            IngredientCreate(
+                component_entity_id="ent_ampicillin",
+                amount="100 mg"
+            )
+        ],
+        fields=benchling.models.fields({
+            "pH": "7.0",
+            "sterilized": "Yes"
+        })
+    )
+)
+```
+
+### Registry Operations
+
+**Direct Registry Registration:**
+```python
+# Register entity upon creation
+registered_seq = benchling.dna_sequences.create(
+    DnaSequenceCreate(
+        name="Construct-001",
+        bases="ATCG",
+        is_circular=True,
+        folder_id="fld_abc123",
+        entity_registry_id="src_abc123",
+        naming_strategy="NEW_IDS"  # or "IDS_FROM_NAMES"
+    )
+)
+print(f"Registry ID: {registered_seq.registry_id}")
+```
+
+**Naming Strategies:**
+- `NEW_IDS`: Benchling generates new registry IDs
+- `IDS_FROM_NAMES`: Use entity names as registry IDs (names must be unique)
+
+## Inventory Management
+
+### Containers
+
+```python
+from benchling_sdk.models import ContainerCreate, ContainerUpdate
+
+# Create
+container = benchling.containers.create(
+    ContainerCreate(
+        name="Sample-001-Tube",
+        schema_id="cont_schema_abc123",
+        barcode="CONT001",
+        parent_storage_id="box_abc123",  # Place in box
+        fields=benchling.models.fields({
+            "concentration": "100 ng/μL",
+            "volume": "50 μL",
+            "sample_type": "gDNA"
+        })
+    )
+)
+
+# Update location
+benchling.containers.transfer(
+    container_id=container.id,
+    destination_id="box_xyz789"
+)
+
+# Update properties
+updated = benchling.containers.update(
+    container_id=container.id,
+    container=ContainerUpdate(
+        fields=benchling.models.fields({
+            "volume": "45 μL",
+            "notes": "Used 5 μL for PCR"
+        })
+    )
+)
+
+# Check out
+benchling.containers.check_out(
+    container_id=container.id,
+    comment="Taking to bench"
+)
+
+# Check in
+benchling.containers.check_in(
+    container_id=container.id,
+    location_id="bench_location_abc"
+)
+```
+
+### Boxes
+
+```python
+from benchling_sdk.models import BoxCreate
+
+box = benchling.boxes.create(
+    BoxCreate(
+        name="Freezer-A-Box-01",
+        schema_id="box_schema_abc123",
+        parent_storage_id="loc_freezer_a",
+        barcode="BOX001",
+        fields=benchling.models.fields({
+            "box_type": "81-place",
+            "temperature": "-80C"
+        })
+    )
+)
+
+# List containers in box
+containers = benchling.containers.list(
+    parent_storage_id=box.id
+)
+```
+
+### Locations
+
+```python
+from benchling_sdk.models import LocationCreate
+
+location = benchling.locations.create(
+    LocationCreate(
+        name="Freezer A - Shelf 2",
+        parent_storage_id="loc_freezer_a",
+        barcode="LOC-A-S2"
+    )
+)
+```
+
+### Plates
+
+```python
+from benchling_sdk.models import PlateCreate, WellCreate
+
+# Create 96-well plate
+plate = benchling.plates.create(
+    PlateCreate(
+        name="PCR-Plate-001",
+        schema_id="plate_schema_abc123",
+        barcode="PLATE001",
+        wells=[
+            WellCreate(
+                position="A1",
+                entity_id="sample_entity_abc"
+            ),
+            WellCreate(
+                position="A2",
+                entity_id="sample_entity_xyz"
+            )
+            # ... more wells
+        ]
+    )
+)
+```
+
+## Notebook Operations
+
+### Entries
+
+```python
+from benchling_sdk.models import EntryCreate, EntryUpdate
+
+# Create entry
+entry = benchling.entries.create(
+    EntryCreate(
+        name="Cloning Experiment 2025-10-20",
+        folder_id="fld_abc123",
+        schema_id="entry_schema_abc123",
+        fields=benchling.models.fields({
+            "objective": "Clone GFP into pET28a",
+            "date": "2025-10-20",
+            "experiment_type": "Molecular Biology"
+        })
+    )
+)
+
+# Update entry
+updated_entry = benchling.entries.update(
+    entry_id=entry.id,
+    entry=EntryUpdate(
+        fields=benchling.models.fields({
+            "results": "Successful cloning, 10 colonies",
+            "notes": "Colony 5 shows best fluorescence"
+        })
+    )
+)
+```
+
+### Linking Entities to Entries
+
+```python
+# Link DNA sequence to entry
+link = benchling.entry_links.create(
+    entry_id="entry_abc123",
+    entity_id="seq_xyz789"
+)
+
+# List links for an entry
+links = benchling.entry_links.list(entry_id="entry_abc123")
+```
+
+## Workflow Management
+
+### Tasks
+
+```python
+from benchling_sdk.models import WorkflowTaskCreate, WorkflowTaskUpdate
+
+# Create task
+task = benchling.workflow_tasks.create(
+    WorkflowTaskCreate(
+        name="PCR Amplification",
+        workflow_id="wf_abc123",
+        assignee_id="user_abc123",
+        schema_id="task_schema_abc123",
+        fields=benchling.models.fields({
+            "template": "seq_abc123",
+            "primers": "Forward: ATCG, Reverse: CGAT",
+            "priority": "High"
+        })
+    )
+)
+
+# Update status
+completed_task = benchling.workflow_tasks.update(
+    task_id=task.id,
+    workflow_task=WorkflowTaskUpdate(
+        status_id="status_complete_abc123",
+        fields=benchling.models.fields({
+            "completion_date": "2025-10-20",
+            "yield": "500 ng"
+        })
+    )
+)
+
+# List tasks
+tasks = benchling.workflow_tasks.list(
+    workflow_id="wf_abc123",
+    status_ids=["status_pending", "status_in_progress"]
+)
+```
+
+## Advanced Features
+
+### Pagination
+
+The SDK uses generators for memory-efficient pagination:
+
+```python
+# Automatic pagination
+sequences = benchling.dna_sequences.list()
+
+# Get estimated total count
+total = sequences.estimated_count()
+print(f"Total sequences: {total}")
+
+# Iterate through all pages
+for page in sequences:
+    for seq in page:
+        process(seq)
+
+# Manual page size control
+sequences = benchling.dna_sequences.list(page_size=50)
+```
+
+### Async Task Handling
+
+Some operations are asynchronous and return task IDs:
+
+```python
+from benchling_sdk.helpers.tasks import wait_for_task
+from benchling_sdk.errors import WaitForTaskExpiredError
+
+# Start async operation
+response = benchling.some_bulk_operation(...)
+task_id = response.task_id
+
+# Wait for completion
+try:
+    result = wait_for_task(
+        benchling,
+        task_id=task_id,
+        interval_wait_seconds=2,  # Poll every 2 seconds
+        max_wait_seconds=600       # Timeout after 10 minutes
+    )
+    print("Task completed successfully")
+except WaitForTaskExpiredError:
+    print("Task timed out")
+```
+
+### Error Handling
+
+```python
+from benchling_sdk.errors import (
+    BenchlingError,
+    NotFoundError,
+    ValidationError,
+    UnauthorizedError
+)
+
+try:
+    sequence = benchling.dna_sequences.get(sequence_id="seq_invalid")
+except NotFoundError:
+    print("Sequence not found")
+except UnauthorizedError:
+    print("Insufficient permissions")
+except ValidationError as e:
+    print(f"Invalid data: {e}")
+except BenchlingError as e:
+    print(f"General Benchling error: {e}")
+```
+
+### Retry Strategy
+
+Customize retry behavior:
+
+```python
+from benchling_sdk.benchling import Benchling
+from benchling_sdk.auth.api_key_auth import ApiKeyAuth
+from benchling_sdk.retry import RetryStrategy
+
+# Custom retry configuration
+retry_strategy = RetryStrategy(
+    max_retries=3,
+    backoff_factor=0.5,
+    status_codes_to_retry=[429, 502, 503, 504]
+)
+
+benchling = Benchling(
+    url="https://your-tenant.benchling.com",
+    auth_method=ApiKeyAuth("your_api_key"),
+    retry_strategy=retry_strategy
+)
+
+# Disable retries
+benchling = Benchling(
+    url="https://your-tenant.benchling.com",
+    auth_method=ApiKeyAuth("your_api_key"),
+    retry_strategy=RetryStrategy(max_retries=0)
+)
+```
+
+### Custom API Calls
+
+For unsupported endpoints:
+
+```python
+# GET request with model parsing
+from benchling_sdk.models import DnaSequence
+
+response = benchling.api.get_modeled(
+    path="/api/v2/dna-sequences/seq_abc123",
+    response_type=DnaSequence
+)
+
+# POST request
+from benchling_sdk.models import DnaSequenceCreate
+
+response = benchling.api.post_modeled(
+    path="/api/v2/dna-sequences",
+    request_body=DnaSequenceCreate(...),
+    response_type=DnaSequence
+)
+
+# Raw requests
+raw_response = benchling.api.get(
+    path="/api/v2/custom-endpoint",
+    params={"key": "value"}
+)
+```
+
+### Batch Operations
+
+Efficiently process multiple items:
+
+```python
+# Bulk create
+from benchling_sdk.models import DnaSequenceCreate
+
+sequences_to_create = [
+    DnaSequenceCreate(name=f"Seq-{i}", bases="ATCG", folder_id="fld_abc")
+    for i in range(100)
+]
+
+# Create in batches
+batch_size = 10
+for i in range(0, len(sequences_to_create), batch_size):
+    batch = sequences_to_create[i:i+batch_size]
+    for seq in batch:
+        benchling.dna_sequences.create(seq)
+```
+
+### Schema Fields Helper
+
+Convert dictionaries to Fields objects:
+
+```python
+# Using fields helper
+fields_dict = {
+    "concentration": "100 ng/μL",
+    "volume": "50 μL",
+    "quality_score": "8.5",
+    "date_prepared": "2025-10-20"
+}
+
+fields = benchling.models.fields(fields_dict)
+
+# Use in create/update
+container = benchling.containers.create(
+    ContainerCreate(
+        name="Sample-001",
+        schema_id="schema_abc",
+        fields=fields
+    )
+)
+```
+
+### Forward Compatibility
+
+The SDK handles unknown API values gracefully:
+
+```python
+# Unknown enum values are preserved
+entity = benchling.dna_sequences.get("seq_abc")
+# Even if API returns new enum value not in SDK, it's preserved
+
+# Unknown polymorphic types return UnknownType
+from benchling_sdk.models import UnknownType
+
+if isinstance(entity, UnknownType):
+    print(f"Unknown type: {entity.type}")
+    # Can still access raw data
+    print(entity.raw_data)
+```
+
+## Best Practices
+
+### Use Type Hints
+
+```python
+from benchling_sdk.models import DnaSequence, DnaSequenceCreate
+from typing import List
+
+def create_sequences(names: List[str], folder_id: str) -> List[DnaSequence]:
+    sequences = []
+    for name in names:
+        seq = benchling.dna_sequences.create(
+            DnaSequenceCreate(
+                name=name,
+                bases="ATCG",
+                folder_id=folder_id
+            )
+        )
+        sequences.append(seq)
+    return sequences
+```
+
+### Efficient Filtering
+
+Use API filters instead of client-side filtering:
+
+```python
+# Good - filter on server
+sequences = benchling.dna_sequences.list(
+    folder_id="fld_abc123",
+    schema_id="ts_abc123"
+)
+
+# Bad - loads everything then filters
+all_sequences = benchling.dna_sequences.list()
+filtered = [s for page in all_sequences for s in page if s.folder_id == "fld_abc123"]
+```
+
+### Resource Cleanup
+
+```python
+# Archive old entities
+cutoff_date = "2024-01-01"
+sequences = benchling.dna_sequences.list()
+
+for page in sequences:
+    for seq in page:
+        if seq.created_at < cutoff_date:
+            benchling.dna_sequences.archive(
+                sequence_id=seq.id,
+                reason="Archiving old sequences"
+            )
+```
+
+## Troubleshooting
+
+### Common Issues
+
+**Import Errors:**
+```python
+# Wrong
+from benchling_sdk import Benchling  # ImportError
+
+# Correct
+from benchling_sdk.benchling import Benchling
+```
+
+**Field Validation:**
+```python
+# Fields must match schema
+# Check schema field types in Benchling UI
+fields = benchling.models.fields({
+    "numeric_field": "123",    # Should be string even for numbers
+    "date_field": "2025-10-20", # Format: YYYY-MM-DD
+    "dropdown_field": "Option1" # Must match dropdown options exactly
+})
+```
+
+**Pagination Exhaustion:**
+```python
+# Generators can only be iterated once
+sequences = benchling.dna_sequences.list()
+for page in sequences:  # First iteration OK
+    pass
+for page in sequences:  # Second iteration returns nothing!
+    pass
+
+# Solution: Create new generator
+sequences = benchling.dna_sequences.list()  # New generator
+```
+
+## References
+
+- **SDK Source:** https://github.com/benchling/benchling-sdk
+- **SDK Docs:** https://benchling.com/sdk-docs/
+- **API Reference:** https://benchling.com/api/reference
+- **Common Examples:** https://docs.benchling.com/docs/common-sdk-interactions-and-examples