- VCFs must be single-sample (multi-sample not supported)
- Index files (.csi or .tbi) are required for all VCF/BCF files
- Add indexing examples with bcftools and tabix
- Document requirements prominently in both main skill and ingestion guide
- Add comprehensive TileDB-VCF skill by Jeremy Leipzig
- Covers open source TileDB-VCF for learning and moderate-scale work
- Emphasizes TileDB-Cloud for large-scale production genomics (1000+ samples)
- Includes detailed reference documentation:
* ingestion.md - Dataset creation and VCF ingestion
* querying.md - Efficient variant queries
* export.md - Data export and format conversion
* population_genomics.md - GWAS and population analysis workflows
- Features accurate TileDB-Cloud API patterns from official repository
- Highlights scale transition: open source → TileDB-Cloud for enterprise
