% One-Page Treatment Plan Template
% Concise, clinician-focused treatment recommendation
% Modeled after precision oncology reports and clinical decision support cards
% Last updated: 2025

\documentclass[10pt,letterpaper]{article}

% Minimal packages for clean, dense layout
\usepackage[top=0.5in,bottom=0.5in,left=0.6in,right=0.6in]{geometry}
\usepackage{amsmath,amssymb}
\usepackage[utf8]{inputenc}
\usepackage{graphicx}
\usepackage{array}
\usepackage{booktabs}
\usepackage{enumitem}
\usepackage{xcolor}
\usepackage{fancyhdr}
\usepackage{tabularx}
\usepackage[most]{tcolorbox}
\usepackage{multicol}

% Compact spacing
\setlist{nosep,leftmargin=*,itemsep=0pt,topsep=2pt}
\setlength{\parindent}{0pt}
\setlength{\parskip}{4pt}

% No page numbers for single page
\pagestyle{empty}

% Section formatting - compact
\usepackage{titlesec}
\titlespacing*{\section}{0pt}{8pt}{4pt}
\titlespacing*{\subsection}{0pt}{6pt}{3pt}
\titleformat{\section}{\normalsize\bfseries\sffamily}{\thesection}{0em}{}
\titleformat{\subsection}{\small\bfseries\sffamily}{\thesubsection}{0em}{}

% Color scheme
\definecolor{headerblue}{RGB}{0,102,153}
\definecolor{lightgray}{RGB}{240,240,240}
\definecolor{darkgray}{RGB}{80,80,80}

\begin{document}

% ========== TITLE ==========
\begin{center}
{\small\textit{PRECISION MEDICINE / CLINICAL RECOMMENDATION}}\\[2pt]
{\Large\bfseries\sffamily [Treatment Type]}\\[1pt]
{\normalsize\textit{[Condition/Disease Name]}}
\end{center}

\vspace{-8pt}

% ========== PATIENT/CASE INFO BOX ==========
\begin{tcolorbox}[
    colback=lightgray,
    colframe=headerblue,
    boxrule=0.5pt,
    arc=2pt,
    left=4pt,right=4pt,top=3pt,bottom=3pt,
    fontupper=\small
]
\textbf{Patient ID:} [De-identified ID] \hfill \textbf{Date:} \today\\
\textbf{Diagnosis:} [Primary diagnosis + ICD-10] \hfill \textbf{Stage/Grade:} [If applicable]\\
\textbf{Age/Sex:} [Age range, sex] \hfill \textbf{Molecular Profile:} [Key biomarkers or cluster, if applicable]
\end{tcolorbox}

\vspace{4pt}

% ========== TWO-COLUMN LAYOUT FOR EFFICIENCY ==========
\begin{multicols}{2}

% ========== LEFT COLUMN ==========

\section*{TARGET PATIENT POPULATION}
{\small
\textbf{Number of Patients:} [N (\% of cohort)]\\
\textbf{Key Features:} [Brief demographic or clinical features]\\
\textbf{Inclusion Criteria:} [1-2 key criteria]
}

\section*{PRIMARY TREATMENT REGIMEN}
{\small
\begin{enumerate}[leftmargin=12pt]
    \item \textbf{[Intervention 1]:} [Specific details]
    \begin{itemize}
        \item Dose: [specific dosing]
        \item Frequency: [schedule]
        \item Duration: [timeframe]
    \end{itemize}
    
    \item \textbf{[Intervention 2]:} [Specific details]
    \begin{itemize}
        \item [Key parameters]
    \end{itemize}
    
    \item \textbf{[Intervention 3]:} [Optional, if needed]
    \begin{itemize}
        \item [Key parameters]
    \end{itemize}
\end{enumerate}
}

\section*{SUPPORTIVE CARE}
{\small
\begin{itemize}
    \item \textbf{[Supportive Med 1]:} [dose/frequency]
    \item \textbf{[Supportive Med 2]:} [dose/frequency]
    \item \textbf{[Other support]:} [brief description]
\end{itemize}
}

\section*{RATIONALE}
{\small
[1-3 sentences explaining why this regimen is appropriate for this patient. Include key pathophysiology, guideline alignment, or molecular rationale if applicable.]
}

\columnbreak

% ========== RIGHT COLUMN ==========

\section*{MOLECULAR TARGETS / RISK FACTORS}
{\small
\begin{itemize}
    \item \textbf{[Target/Factor 1]:} [Value/status]
    \item \textbf{[Target/Factor 2]:} [Value/status]
    \item \textbf{[Target/Factor 3]:} [Value/status]
\end{itemize}
}

\section*{EVIDENCE LEVEL}
{\small
\textbf{[Level designation - e.g., Level 1, FDA approved]}\\
\textbf{Supporting Evidence:} [Guideline name/year or key trial]\\
\textbf{References:} [1-2 key citations in abbreviated format]
}

\section*{MONITORING REQUIREMENTS}
{\small
\begin{tabular}{@{}ll@{}}
\textbf{Parameter} & \textbf{Frequency} \\
\hline
[Lab/vital 1] & [e.g., Weekly x 4 weeks] \\
[Lab/vital 2] & [e.g., Monthly x 3 months] \\
[Lab/vital 3] & [e.g., Every 3 months] \\
[Assessment tool] & [e.g., Baseline, 3 mo, 6 mo] \\
\end{tabular}
}

\section*{EXPECTED CLINICAL BENEFIT}
{\small
\textbf{Primary Outcome:} [e.g., Median OS 20.9 months]\\
\textbf{Timeline:} [e.g., Response assessment at 12 weeks]\\
\textbf{Success Criteria:} [Specific metrics for goal achievement]
}

\section*{CRITICAL DECISION POINTS}
{\small
\begin{itemize}
    \item \textbf{Hold treatment if:} [Specific criteria]
    \item \textbf{Dose modify for:} [Specific criteria]
    \item \textbf{Discontinue if:} [Specific criteria]
\end{itemize}
}

\end{multicols}

\vspace{4pt}

% ========== BOTTOM SECTION - FULL WIDTH ==========
\begin{tcolorbox}[
    colback=yellow!10,
    colframe=red!60!black,
    boxrule=0.8pt,
    arc=2pt,
    left=4pt,right=4pt,top=3pt,bottom=3pt,
    fontupper=\small\bfseries
]
\textbf{EMERGENCY CONTACTS / URGENT CONCERNS:} \\
{\small\normalfont
Call [clinic/provider] immediately for: [List 2-3 red flag symptoms]. \\
Emergency: 911 | Clinic: [phone] | After-hours: [phone] | Pharmacy: [phone]
}
\end{tcolorbox}

\vspace{6pt}

{\footnotesize\textit{
Prepared by: [Provider name, credentials] | Plan created: \today | Next review: [date] \\
HIPAA Notice: This document contains de-identified patient information per Safe Harbor standards.
}}

\end{document}

