150 lines
6.9 KiB
TeX
150 lines
6.9 KiB
TeX
% Clinical Decision Support Color Schemes
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% For use in LaTeX documents
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% ============================================================================
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% PRIMARY THEME COLORS
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% ============================================================================
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% Header and structural elements
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\definecolor{headerblue}{RGB}{0,102,204} % Section headers, titles
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\definecolor{highlightgray}{RGB}{240,240,240} % Background boxes
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% ============================================================================
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% RECOMMENDATION STRENGTH COLORS
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% ============================================================================
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% Strong recommendations (benefits clearly outweigh risks)
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\definecolor{stronggreen}{RGB}{0,153,76} % Grade 1A, 1B
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\definecolor{strongdark}{RGB}{0,120,60} % Darker variant for emphasis
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% Conditional recommendations (trade-offs exist)
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\definecolor{conditionalyellow}{RGB}{255,193,7} % Grade 2A, 2B, 2C
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\definecolor{conditionalamber}{RGB}{255,160,0} % Darker variant
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% Research/Investigational (insufficient evidence)
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\definecolor{researchblue}{RGB}{33,150,243} % Clinical trials
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\definecolor{researchdark}{RGB}{25,118,210} % Darker variant
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% Not recommended / Contraindicated
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\definecolor{warningred}{RGB}{204,0,0} % Strong recommendation against
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\definecolor{dangerred}{RGB}{220,20,60} % Critical warnings, urgent actions
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% ============================================================================
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% URGENCY LEVELS (Clinical Pathways)
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% ============================================================================
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\definecolor{urgentred}{RGB}{220,20,60} % Immediate action (<1 hour)
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\definecolor{semiurgent}{RGB}{255,152,0} % Action within 24 hours
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\definecolor{routineblue}{RGB}{100,181,246} % Routine care (>24 hours)
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\definecolor{actiongreen}{RGB}{0,153,76} % Standard interventions
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% ============================================================================
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% BIOMARKER CATEGORIES
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% ============================================================================
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% Alteration types
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\definecolor{mutationred}{RGB}{244,67,54} % Point mutations, SNVs
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\definecolor{amplificationblue}{RGB}{33,150,243} % Copy number gains
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\definecolor{deletionpurple}{RGB}{156,39,176} % Copy number losses
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\definecolor{fusionpurple}{RGB}{156,39,176} % Gene fusions/rearrangements
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\definecolor{expressionorange}{RGB}{255,152,0} % Expression alterations
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% Actionability tiers
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\definecolor{tier1green}{RGB}{0,153,76} % FDA-approved therapy
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\definecolor{tier2orange}{RGB}{255,152,0} % Clinical trial/off-label
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\definecolor{tier3gray}{RGB}{158,158,158} % VUS, no action
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% ============================================================================
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% STATISTICAL SIGNIFICANCE
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% ============================================================================
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\definecolor{significant}{RGB}{0,153,76} % p < 0.05, statistically significant
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\definecolor{trending}{RGB}{255,193,7} % p = 0.05-0.10, trending
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\definecolor{nonsignificant}{RGB}{158,158,158} % p > 0.10, not significant
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% ============================================================================
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% OUTCOME CATEGORIES
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% ============================================================================
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% Response assessment (RECIST)
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\definecolor{completeresponse}{RGB}{0,153,76} % CR (complete response)
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\definecolor{partialresponse}{RGB}{76,175,80} % PR (partial response)
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\definecolor{stabledisease}{RGB}{255,193,7} % SD (stable disease)
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\definecolor{progressivedisease}{RGB}{244,67,54} % PD (progressive disease)
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% Survival outcomes
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\definecolor{survivedgreen}{RGB}{0,153,76} % Patient alive
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\definecolor{eventred}{RGB}{244,67,54} % Event occurred (death, progression)
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\definecolor{censoredgray}{RGB}{158,158,158} % Censored observation
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% ============================================================================
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% ADVERSE EVENT SEVERITY (CTCAE)
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% ============================================================================
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\definecolor{grade1}{RGB}{255,235,59} % Mild
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\definecolor{grade2}{RGB}{255,193,7} % Moderate
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\definecolor{grade3}{RGB}{255,152,0} % Severe
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\definecolor{grade4}{RGB}{244,67,54} % Life-threatening
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\definecolor{grade5}{RGB}{198,40,40} % Fatal
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% ============================================================================
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% COLORBLIND-SAFE PALETTE (Okabe-Ito)
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% ============================================================================
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% Use these for graphs/figures to ensure accessibility
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\definecolor{okabe1}{RGB}{230,159,0} % Orange
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\definecolor{okabe2}{RGB}{86,180,233} % Sky blue
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\definecolor{okabe3}{RGB}{0,158,115} % Bluish green
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\definecolor{okabe4}{RGB}{240,228,66} % Yellow
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\definecolor{okabe5}{RGB}{0,114,178} % Blue
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\definecolor{okabe6}{RGB}{213,94,0} % Vermillion
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\definecolor{okabe7}{RGB}{204,121,167} % Reddish purple
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% ============================================================================
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% USAGE EXAMPLES
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% ============================================================================
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% Example 1: Strong recommendation box
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% \begin{tcolorbox}[enhanced,colback=stronggreen!10,colframe=stronggreen,
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% title={\textbf{STRONG RECOMMENDATION} \hfill \textbf{GRADE: 1A}}]
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% We recommend osimertinib for EGFR-mutated NSCLC...
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% \end{tcolorbox}
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% Example 2: Conditional recommendation box
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% \begin{tcolorbox}[enhanced,colback=conditionalyellow!10,colframe=conditionalyellow,
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% title={\textbf{CONDITIONAL RECOMMENDATION} \hfill \textbf{GRADE: 2B}}]
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% We suggest considering maintenance therapy...
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% \end{tcolorbox}
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% Example 3: Biomarker alteration
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% \colorbox{mutationred!60}{\textcolor{white}{\textbf{MUTATION}}}
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% Example 4: Statistical significance in table
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% \cellcolor{significant!20} p < 0.001
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% Example 5: Adverse event severity
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% \textcolor{grade3}{Grade 3} or \colorbox{grade3!30}{Grade 3}
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% ============================================================================
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% ACCESSIBILITY NOTES
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% ============================================================================
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% 1. Always use sufficient color contrast (4.5:1 ratio for normal text)
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% 2. Do not rely on color alone - use symbols/text as well
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% 3. Test in grayscale to ensure readability
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% 4. Use Okabe-Ito palette for colorblind accessibility in figures
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% 5. Add text labels to colored boxes ("STRONG", "CONDITIONAL", etc.)
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% ============================================================================
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% STYLE CONSISTENCY
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% ============================================================================
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% Font: Helvetica (sans-serif) for clinical documents
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% Margins: 0.5 inches for compact professional appearance
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% Font sizes: 10pt body, 11pt subsections, 12-14pt headers
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% Line spacing: Compact (minimal whitespace for dense information)
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% Boxes: tcolorbox with rounded corners, colored backgrounds at 10-20% opacity
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% End of color scheme definitions
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